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Uroporphyrinogen III is converted to coproporphyrinogen III via the enzyme uroporphyrinogen decarboxylase (heme synthesis). Deficiency of this enzyme causes which condition?

1) Porphyria cutanea tarda
2) Hemochromatosis
3) Sideroblastic anemia
4) Thalassemia

User Chashikajw
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Final answer:

Deficiency of uroporphyrinogen decarboxylase causes Porphyria cutanea tarda.

Step-by-step explanation:

Deficiency of the enzyme uroporphyrinogen decarboxylase, which converts uroporphyrinogen III to coproporphyrinogen III in the heme synthesis pathway, causes Porphyria cutanea tarda. Porphyria cutanea tarda is a disorder characterized by the abnormal accumulation of porphyrins, resulting in photosensitivity and skin fragility.

User Tomas Karban
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