Final answer:
Tramadol should not be used with SSRIs because both can increase serotonin levels in the brain, potentially leading to serotonin syndrome, a serious medical condition.
Step-by-step explanation:
Tramadol can indeed cause serotonin syndrome, which is a potentially life-threatening condition that occurs when there is an excess of serotonin in the brain. This can happen if Tramadol is used in combination with other drugs that affect serotonin levels. Among the options provided, tramadol should not be used with C) SSRIs (Selective Serotonin Reuptake Inhibitors) because SSRIs block the reuptake of serotonin into the presynaptic neuron, leading to an increase in serotonin in the synaptic cleft. Using Tramadol with SSRIs can further augment this effect, significantly raising serotonin levels and increasing the risk of serotonin syndrome.
Tramadol can cause serotonin syndrome and should not be used with certain medications. One of the medications that should be avoided is selective serotonin reuptake inhibitors (SSRIs) which are commonly used to treat depression. SSRIs work by blocking the reuptake of serotonin, causing an increase in serotonin levels in the synaptic cleft. When combined with tramadol, the risk of serotonin syndrome can be heightened.