Question

The acute phase response has what effect on serum iron and ferritin levels?

1: Increases serum iron levels and increases serum ferritin levels
2: Increases serum iron levels and decreases serum ferritin levels
3: Decreases serum iron levels and decreases serum ferritin levels
4: Decreases serum iron levels and increases serum ferritin levels

Answer 1

During the acute phase response, serum iron levels decrease and serum ferritin levels increase as iron is sequestered in the form of ferritin as a defense mechanism.

Step-by-step explanation:

The acute phase response typically causes a decrease in serum iron levels and an increase in serum ferritin levels. This occurs because, during an inflammatory response, the body aims to limit the availability of iron in the bloodstream to reduce the risk of bacterial growth, as many bacteria require iron for proliferation. Consequently, iron is sequestered in storage forms, particularly ferritin, within cells such as hepatocytes in the liver. The ferritin binds iron, removing it from serum circulation and increases in concentration during these conditions as an acute-phase reactant.