Question

What vitamin absorption is most likely to be impaired with chronic use of proton pump inhibitor therapy?

1: Vitamin B3
2: Vitamin B1
3: Vitamin B6
4: Vitamin B12

Answer 1

Chronic use of PPI therapy is most likely to impair the absorption of Vitamin B12, as stomach acidity, which is necessary for intrinsic factor secretion and B12 uptake, is reduced.

Step-by-step explanation:

The vitamin absorption most likely to be impaired with chronic use of proton pump inhibitor (PPI) therapy is of Vitamin B12 (Cobalamin). PPIs reduce the production of stomach acid, which is necessary for the absorption of Vitamin B12. The absorption of Vitamin B12 normally involves the secretion of intrinsic factor in the stomach that binds to the vitamin, forming a complex that is later absorbed in the terminal ileum by endocytosis. With chronic PPI use, the decreased acidity in the stomach can lead to a deficiency of intrinsic factor and subsequently impair the absorption of Vitamin B12, possibly leading to pernicious anemia.