Final answer:
NSAIDs are avoided during the third trimester due to the risk of causing premature closure of the ductus arteriosus in the fetus, reduced prostaglandin levels leading to labor complications, increased bleeding risks, and potential for kidney damage in the mother.
Step-by-step explanation:
Nonsteroidal anti-inflammatory drugs (NSAIDs) should not be used during the third trimester of pregnancy because they can cause serious complications for both the mother and the fetus. NSAIDs can lead to the premature closure of the ductus arteriosus, a vital blood vessel in the fetal heart that should remain open during gestation and close naturally after birth. Closing too early can lead to pulmonary hypertension and other significant cardiac problems for the newborn. Additionally, NSAIDs can inhibit prostaglandin production, which is important for labor; reducing prostaglandin levels might lead to reduced uterine contractions and labor delays or complications. There is also an increased risk of bleeding complications for both the mother and baby, as NSAIDs can affect platelet function and blood clotting.
Furthermore, expectant mothers face a higher risk of kidney issues with the use of NSAIDs due to changes in their renal system during the third trimester.During the third trimester of pregnancy, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) such as aspirin should be avoided. This is because NSAIDs can increase the risk of complications for both the mother and the baby. The use of NSAIDs can potentially cause premature closure of the blood vessels in the baby's heart, leading to a condition called fetal ductus arteriosus constriction, which can be life-threatening. Additionally, NSAIDs can increase the risk of bleeding in the mother and may affect kidney function.