Final answer:
Disease-oriented evidence focuses on the physiological aspects and treatment of diseases, while patient-oriented evidence focuses on the actual impact on patient's lives including mortality, quality of life, and symptom improvement.
Step-by-step explanation:
The difference between disease-oriented evidence and patient-oriented evidence that matters lies in the focus of the outcomes considered. Disease-oriented evidence prioritizes the pathophysiological outcomes and often concentrates on the disease itself. It measures components like causative agents of food poisoning or a disease's pathogen during an outbreak. Patient-oriented evidence, on the other hand, focuses on outcomes that matter directly to patient care, such as mortality, quality of life, and symptom improvement. While identifying a disease's causative agent can lead to appropriate treatments for food poisoning or containment strategies for epidemics, patient-oriented evidence is centered around the actual impact on patients' lives, considering individual patient values and conditions.