Final answer:
Systemic mycoses are primarily acquired through inhaling fungal spores, which can cause diseases like coccidioidomycosis and histoplasmosis, especially in those with weakened immune systems.
Step-by-step explanation:
Most systemic mycoses are acquired from inhaling spores. These infections commonly enter the body through the respiratory system. For instance, diseases such as coccidioidomycosis (valley fever) and histoplasmosis are contracted when fungal spores are inhaled. In these cases, the spores can develop in the lungs and even disseminate internally, affecting various organs. In individuals with compromised immune systems, respiratory mycoses are more likely to result in serious infection because these fungi are only virulent enough to establish infection in such patients. While spores can also cause infection through puncture wounds or by being ingested, inhalation is the most common route for systemic mycoses.