The highest frequency of babies born with Down syndrome is among older mothers, with the risk significantly increasing past the age of 35 due to chromosomal abnormalities.
Babies with Down syndrome are born at the highest frequency among older mothers. Although many factors such as lifestyle can play a role, the core risk factor for having a baby with Down syndrome increases significantly with maternal age, particularly for women age 35 and older. As women age, chromosomal abnormalities during cell division become more common, leading to an increased incidence of trisomy 21, which is the genetic condition responsible for Down syndrome.
In conclusion, while individuals with Down syndrome can lead fulfilling lives and contribute to society, it's important for prospective parents, especially older mothers, to be aware of the increased risk as they make family planning decisions.