Question

Pharmacologic agents such as histamine2-receptor antagonists (H2 blockers) and proton-pump inhibitors (PPIs) are commonly prescribed for a variety of upper GI disorders for the prevention of gastric ulceration. Prolonged use of these medications may contribute to deficiency of this of the following micronutrients?

1: Iron
2: Potassium
3: Vitamin B6
4: Vitamin B12

Answer 1

Prolonged use of H2 blockers and PPIs, which reduce stomach acid production, can lead to a Vitamin B12 deficiency, since stomach acid is needed for its absorption.

Step-by-step explanation:

Pharmacologic agents such as Histamine2-receptor antagonists (H2 blockers) and proton-pump inhibitors (PPIs) are commonly prescribed for conditions such as ulcers, gastroesophageal reflux disease (GERD), and excessive acidity of the stomach. The prolonged use of these medications can lead to nutrient deficiencies due to their mechanism of action that involves reducing the production of stomach acid, which is necessary for the absorption of certain micronutrients. Of the options provided, prolonged use of these medications may contribute to a deficiency of Vitamin B12. This vitamin requires stomach acid for its absorption from food, and a reduction in stomach acid can hinder this process, leading to potential deficiency.