Final answer:
Native Americans suffered the most from the Columbian Exchange due to diseases and loss of land, while Europeans gained economically from new resources.
Step-by-step explanation:
The group that suffered the most from the Columbian Exchange was Native Americans, while Europeans gained from it. Native Americans suffered from diseases and loss of land, which greatly impacted their populations. They were also introduced to diseases that nearly destroyed them, as they had no immunity to European diseases. On the other hand, Europeans gained new resources, such as foods, plants, and animals, which they turned into commodities to be bought and sold. This led to economic growth for Europeans.