Question

G6PD deficiency renders RBCs susceptible to oxidative stress due to decreased NADPH and thus decreased reduced glutathione regeneration. What is the effect of G6PD deficiency on RBCs?

1) Increased NADPH and reduced glutathione regeneration
2) Decreased NADPH and reduced glutathione regeneration
3) Increased NADPH and increased reduced glutathione regeneration
4) Decreased NADPH and increased reduced glutathione regeneration

Answer 1

G6PD deficiency decreases the production of NADPH and reduced glutathione in red blood cells.

Step-by-step explanation:

G6PD deficiency decreases the production of NADPH and reduced glutathione in red blood cells. NADPH is necessary for the regeneration of reduced glutathione, which acts as an antioxidant to protect the cells from oxidative stress. Therefore, the effect of G6PD deficiency on RBCs is decreased NADPH and reduced glutathione regeneration.