Final answer:
The last resort treatment for IgG-mediated hemolytic anemia is a splenectomy, which is considered after other treatments, like immunosuppressive, have failed.
Step-by-step explanation:
The last resort treatment for IgG-mediated hemolytic anemia is splenectomy. This type of anemia is a form of Type II hypersensitivity, where IgG antibodies target and lead to the lysis of red blood cells by the complement system. The treatment strategy for IgG-mediated hemolytic anemia usually begins with immunosuppressive therapy, such as steroids to decrease antibody production. If this is not effective and the condition is severe, or if the patient relapses after treatment, a splenectomy may be considered because the spleen is the site where most antibody-coated red blood cells are destroyed. A splenectomy could reduce the destruction of red blood cells and improve anemia, but it is regarded as the last resort due to the increased risk of infections and other complications after the operation.