Question

The levels of TBG and total thyroid hormone are decreased with hepatic failure, steroid use, and nephrotic syndrome, due to decreased TBG synthesis by the liver. How is decreased TBG detected?

1) Increased resin uptake
2) Decreased resin uptake
3) Increased TBG synthesis
4) Decreased TBG synthesis

Answer 1

Decreased TBG can be detected through increased resin uptake.

Step-by-step explanation:

Decreased TBG can be detected through increased resin uptake. When TBG levels decrease, there is less binding of thyroid hormones to TBG, resulting in more unbound hormones in the blood. This leads to an increase in the uptake of radioactive resin by the unbound hormones. By measuring the amount of resin uptake, we can indirectly determine the levels of TBG in the blood.