Final answer:
The Senate is composed of members serving 6-year terms for an entire state, while the House members serve 2-year terms and represent specific congressional districts in a state.
Step-by-step explanation:
The most accurate comparison regarding membership in the U.S. Senate and House of Representatives is that Senate members are elected to 6-year terms while House members serve 2-year terms. Unlike House members who are elected by people in their specific congressional districts, Senators represent the entire state. Moreover, the Senate has fewer members (100) compared to the House of Representatives which has 435 members.