Question

The benefit of selective COX-2 inhibitors in the treatment of inflammation is they:

A. Have anti-inflammatory properties, but do not alter the gastric protection provided by COX-1.
B. Are antiemetic and antidiarrheal.
C. Cause platelet aggregation.
D. Do not cross the placenta.

Answer 1

Option (A), Selective COX-2 inhibitors like Celebrex provide anti-inflammatory effects, similar to other NSAIDs, but with a reduced risk of stomach problems since they mainly inhibit the COX-2 enzyme, preserving COX-1's gastric protection.

Step-by-step explanation:

The benefit of selective COX-2 inhibitors in the treatment of inflammation is that they have anti-inflammatory properties, but do not alter the gastric protection provided by COX-1. COX-2 selective inhibitors, like Celebrex (celecoxib), are designed to selectively block the COX-2 enzyme which is more directly involved in causing inflammation and pain, while sparing the COX-1 enzyme that offers a protective effect on the gastric lining.

This selective inhibition helps reduce the risk of gastrointestinal issues that are often associated with traditional nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, and naproxen, which inhibit both COX enzymes.