Final answer:
Trimethoprim and sulfamethoxazole are often used together to target bacterial enzymes, including sulfonamides.
Step-by-step explanation:
The combination often used to target bacterial enzymes, including sulfonamides (sulfa drugs), is Trimethoprim and Sulfamethoxazole. These two drugs work together to inhibit bacterial growth by targeting different steps in the folic acid synthesis pathway. Trimethoprim acts as an antimetabolite, while sulfamethoxazole is a sulfa drug that inhibits an earlier step in the pathway.