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What type of antibiotic is able to cross the LPS layer?

A. Broad-spectrum
B. Narrow-spectrum
C. Lipophilic
D. Parenteral

User Aaditya
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1 Answer

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Final answer:

Option (C), The type of antibiotic capable of crossing the LPS layer is Lipophilic. Lipophilic antibiotics can penetrate the outer membranes of gram-negative bacteria, making them effective for such targets.

Step-by-step explanation:

The type of antibiotic that is able to cross the LPS layer is C. Lipophilic. Lipid-soluble or lipophilic antibiotics have the ability to penetrate the lipopolysaccharide (LPS) layer found in the outer membrane of gram-negative bacteria. This makes them effective in targeting these types of bacteria.

For example, the polymyxins, which include polymyxin B and colistin, are lipophilic antibiotics that target gram-negative bacteria by disrupting their cell membranes. On the contrary, daptomycin, a cyclic lipopeptide, is also lipophilic but specifically targets gram-positive bacteria by a similar mechanism.

Regarding the dental student's questions: 1) The soil bacterium's antimicrobial that was chemically modified to kill both gram-positive and gram-negative bacteria would be considered B. semisynthetic. 3) B. long-term use of broad-spectrum antimicrobials would most likely contribute to the development of a superinfection by eliminating a wide range of the body's normal flora and possibly leading to resistance.

4) An appropriate and convenient route for home administration of an antimicrobial to treat a systemic infection would be A. oral, as it allows self-administration without the need for complex equipment or medical supervision. 5) A clinical situation appropriate for treatment with a narrow-spectrum antimicrobial could be an infection caused by a specific pathogen that is known and targeted, thus preserving the body's normal flora and reducing the risk of resistance or superinfection.

User Maybeshewill
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