Question

Scleroderma is a mixed connective tissue disease. Which of the following would be correct for the way that this disease can affect the renal system of an individual?

A. Scleroderma would not have an affect on the kidneys.
B. Scleroderma would only be a problem for the patient that does not have renal function problems.
C. Scleroderma can cause a narrowing of the lumen of the small interlobular and arcuate arteries.
D. None of the above

Answer 1

Scleroderma can indeed affect the renal system by causing fibrosis that leads to a narrowing of the lumen in the small interlobular and arcuate arteries, potentially leading to hypertension and other severe kidney issues.

Step-by-step explanation:

Scleroderma is an autoimmune disease characterized by the hardening and tightening of the skin and connective tissues. This disease can indeed affect internal organs, including the renal system. When considering how scleroderma can affect the kidneys, the correct answer is C. Scleroderma can cause a narrowing of the lumen of the small interlobular and arcuate arteries. This is due to the excessive deposition of collagen and other extracellular matrix components leading to fibrosis. The resultant vascular narrowing can lead to problems such as renal hypertension, and in severe cases, scleroderma renal crisis, which is a potentially life-threatening complication.