Final answer:
The "I" in the first position of the anticodon indicates that the tRNA can read multiple codons through a process called wobbling.
Step-by-step explanation:
The "I" in the first position of the anticodon indicates that the tRNA can read multiple codons. Specifically, it can pair with three nucleotides, U, C, and A, at the third position of the codon. This is known as wobbling. For example, if a tRNA has an anticodon sequence of GCI, it can base pair with codons for arginine that differ at the third nucleotide, such as GCU, GCG, and GCC.