Question

A rare syndrome characterized by recurrent infections, hemorrhages due to thrombocytopenia, and eczema, is linked to mutations in a gene on the X chromosome. What is the name of this syndrome?

A. Goodpasture syndrome
B. Systemic lupus erythematosus (SLE)
C. Eczema herpeticum
D. X-linked agammaglobulinemia of Bruton
E. Wiskott-Aldrich syndrome

Answer 1

Wiskott-Aldrich syndrome is characterized by recurrent infections, thrombocytopenia-induced hemorrhages, and eczema and is linked to X chromosome mutations. It differs from X-linked agammaglobulinemia of Bruton, involving complex immune deficiencies and broader symptoms. Treatment includes antibiotics, immunoglobulin therapy, and possibly stem cell transplantation.

Step-by-step explanation:

Wiskott-Aldrich Syndrome

The syndrome characterized by recurrent infections, hemorrhages due to thrombocytopenia, and eczema, linked to mutations in a gene on the X chromosome, is known as Wiskott-Aldrich syndrome. Unlike X-linked agammaglobulinemia of Bruton, which involves a deficiency in B cell maturation and a lack of immunoglobulins primarily affecting antibacterial defense, Wiskott-Aldrich syndrome is marked by a broader range of symptoms including a predisposition to autoimmune illnesses and malignancies. Patients with Wiskott-Aldrich syndrome often have mutations in the gene responsible for coding the protein WASP, which plays a crucial role in the cytoskeleton of cells, particularly in the immune system.

Treatment options for Wiskott-Aldrich syndrome typically include prophylactic antibiotics, immunoglobulin replacement therapy, and in some cases, hematopoietic stem cell transplantation. It's crucial for these patients to be managed by a healthcare provider who specializes in immunodeficiency disorders to prevent and treat infections effectively and to manage the autoimmune and malignant complications that are associated with this syndrome.

Answer 2

Wiskott-Aldrich syndrome is characterized by recurrent infections, thrombocytopenia-induced hemorrhages, and eczema and is linked to X chromosome mutations. It differs from X-linked agammaglobulinemia of Bruton, involving complex immune deficiencies and broader symptoms. Treatment includes antibiotics, immunoglobulin therapy, and possibly stem cell transplantation.

Step-by-step explanation:

Wiskott-Aldrich Syndrome

The syndrome characterized by recurrent infections, hemorrhages due to thrombocytopenia, and eczema, linked to mutations in a gene on the X chromosome, is known as Wiskott-Aldrich syndrome. Unlike X-linked agammaglobulinemia of Bruton, which involves a deficiency in B cell maturation and a lack of immunoglobulins primarily affecting antibacterial defense, Wiskott-Aldrich syndrome is marked by a broader range of symptoms including a predisposition to autoimmune illnesses and malignancies. Patients with Wiskott-Aldrich syndrome often have mutations in the gene responsible for coding the protein WASP, which plays a crucial role in the cytoskeleton of cells, particularly in the immune system.

Treatment options for Wiskott-Aldrich syndrome typically include prophylactic antibiotics, immunoglobulin replacement therapy, and in some cases, hematopoietic stem cell transplantation. It's crucial for these patients to be managed by a healthcare provider who specializes in immunodeficiency disorders to prevent and treat infections effectively and to manage the autoimmune and malignant complications that are associated with this syndrome.

Answer 3

Wiskott-Aldrich syndrome is characterized by recurrent infections, thrombocytopenia-induced hemorrhages, and eczema and is linked to X chromosome mutations. It differs from X-linked agammaglobulinemia of Bruton, involving complex immune deficiencies and broader symptoms. Treatment includes antibiotics, immunoglobulin therapy, and possibly stem cell transplantation.

Step-by-step explanation:

Wiskott-Aldrich Syndrome

The syndrome characterized by recurrent infections, hemorrhages due to thrombocytopenia, and eczema, linked to mutations in a gene on the X chromosome, is known as Wiskott-Aldrich syndrome. Unlike X-linked agammaglobulinemia of Bruton, which involves a deficiency in B cell maturation and a lack of immunoglobulins primarily affecting antibacterial defense, Wiskott-Aldrich syndrome is marked by a broader range of symptoms including a predisposition to autoimmune illnesses and malignancies. Patients with Wiskott-Aldrich syndrome often have mutations in the gene responsible for coding the protein WASP, which plays a crucial role in the cytoskeleton of cells, particularly in the immune system.

Treatment options for Wiskott-Aldrich syndrome typically include prophylactic antibiotics, immunoglobulin replacement therapy, and in some cases, hematopoietic stem cell transplantation. It's crucial for these patients to be managed by a healthcare provider who specializes in immunodeficiency disorders to prevent and treat infections effectively and to manage the autoimmune and malignant complications that are associated with this syndrome.