Question

In Goodpasture syndrome, autoantibodies primarily target which type of collagen found in the basement membranes of the lung and kidney?

A. Type I collagen
B. Type II collagen
C. Type III collagen
D. Type IV collagen

Answer 1

Autoantibodies in Goodpasture syndrome primarily target the alpha-3 chain of Type IV collagen in the basement membranes of the lungs and kidneys, causing inflammatory damage typical of Type II hypersensitivity. The correct option is D. Type IV collagen

Step-by-step explanation:

In Goodpasture syndrome, the autoantibodies primarily target Type IV collagen found in the basement membranes of the lung and kidney.

This autoimmune disorder is a classic example of Type II hypersensitivity, where the immune system inappropriately attacks the body's own cells and tissues.

In this condition, antibodies are directed against the alpha-3 chain of Type IV collagen, which is an essential structural component of basement membranes.

These antibodies can lead to an inflammatory response that damages the affected organs, most commonly the kidneys and lungs, resulting in conditions such as glomerulonephritis and pulmonary hemorrhage. The correct option is D. Type IV collagen