Question

Which immune response process is essential for effective antitumor immunity, and which tactics do tumors often employ to evade this immune response?

A. Activation of complement system; suppression of T-cell activity
B. Activation of B cells; upregulation of antigen presentation
C. Generation of antigen-specific cytotoxic T cells (CTLs); recruitment of regulatory T cells (Tregs)
D. Neovascularization; reduced expression of MHC class II

Answer 1

The immune response process essential for effective antitumor immunity is the generation of antigen-specific cytotoxic T cells (CTLs) and the recruitment of regulatory T cells (Tregs). Tumors often evade this immune response by recruiting Tregs and reducing the expression of MHC class II molecules.

Step-by-step explanation:

The immune response process that is essential for effective antitumor immunity is the generation of antigen-specific cytotoxic T cells (CTLs) and the recruitment of regulatory T cells (Tregs). CTLs are responsible for recognizing and killing cancer cells, while Tregs help to regulate the immune response and prevent excessive inflammation. This balance between CTLs and Tregs is critical for effective antitumor immunity.

Tumors often employ tactics to evade this immune response. One common tactic is the recruitment of Tregs, which suppress the activity of CTLs and dampen the immune response. Tumors can also downregulate the expression of MHC class II molecules, which are necessary for antigen presentation to T cells. This reduces the ability of the immune system to recognize and respond to tumor cells.