Question

What is the term for molecules of microbial origin that can non-specifically activate T cells by bridging MHC Class II molecules and the variable region of the T cell receptor?

A. Antigen receptors
B. Complement receptors
C. Fc receptors
D. Membrane immunoglobulin
E. Superantigens

Answer 1

Superantigens are the molecules that can non-specifically activate T cells by bridging MHC Class II molecules and TCR, leading to a robust immune response.

Step-by-step explanation:

The term for molecules of microbial origin that can non-specifically activate T cells by bridging MHC Class II molecules and the variable region of the T cell receptor is Superantigens. Unlike conventional antigens that require antigen processing and presentation to T cells, superantigens can bind outside of the normal antigen-binding groove of MHC Class II molecules and the T cell receptor (TCR). This results in the activation of a large population of T cells, leading to an excessive immune response which can be harmful to the host.