Question

Which primary immunodeficiency syndrome is characterized by an inability to synthesize and secrete IgA subclasses, often resulting in respiratory or gastrointestinal infections and a predilection for allergies and collagen vascular diseases?

A. Severe combined immunodeficiency (SCID)
B. Chronic mucocutaneous candidiasis
C. Common variable immunodeficiency (CVID)
D. X-linked agammaglobulinemia of Bruton
E. Selective IgA deficiency

Answer 1

Selective IgA deficiency is the condition that leads to an inability to produce IgA, causing susceptibility to respiratory and gastrointestinal infections and a higher risk of allergies and autoimmune diseases.

Step-by-step explanation:

The primary immunodeficiency syndrome characterized by an inability to synthesize and secrete IgA subclasses, often resulting in respiratory or gastrointestinal infections and a predilection for allergies and collagen vascular diseases, is Selective IgA deficiency. Individuals with this condition produce normal levels of IgG and IgM but fail to produce secretory IgA, which is crucial for protecting mucosal surfaces against infections.

Due to this deficiency, they are particularly susceptible to lung and gastrointestinal tract infections from various pathogens, as well as an increased likelihood of allergies and autoimmune diseases.