Question

How does the sensitization of mast cells to allergens, such as dust, animal dander, and pollen, primarily occur in the context of allergies?

A. Macrophages present allergens directly to mast cells.
B. B cells release vasoactive amines as a result of allergen exposure.
C. Allergens bind to IgE on the surface of mast cells during sensitization.
D. Th1 cells mediate the interaction between allergens and mast cells.

Answer 1

The sensitization of mast cells to allergens occurs through the binding of allergens to IgE on the surface of mast cells, triggering degranulation and the release of chemical mediators.

Step-by-step explanation:

The sensitization of mast cells to allergens primarily occurs through the binding of allergens to IgE on the surface of mast cells. When a person is first exposed to an allergen, B cells produce IgE antibodies specific to that allergen. These IgE antibodies bind to the Fc receptors on mast cells. Upon subsequent exposure to the allergen, the allergen cross-links the IgE molecules on the mast cells, triggering degranulation and the release of chemical mediators that cause the symptoms of allergies.