Final answer:
Macrophages and dendritic cells are the two primary cell types responsible for the formation of granulomas in response to Mycobacterium infection.
Step-by-step explanation:
The two primary cell types responsible for the formation of granulomas in response to Mycobacterium infection are macrophages and dendritic cells. Macrophages are a type of phagocytic cell that can both engulf and destroy pathogens, while also releasing chemicals that promote inflammation. Dendritic cells, on the other hand, are involved in presenting antigens to T cells and help initiate an immune response. These two cell types work together to form granulomas, which are organized collections of immune cells that surround and contain the Mycobacterium infection.