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In X-linked agammaglobulinemia (XLA), what markers are typically exploited in flow cytometry to diagnose the condition?

A. CD3+
B. CD16+ and CD54+
C. CD19 and CD20
D. Natural killer cells

User Hnm
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1 Answer

6 votes

Final answer:

In X-linked agammaglobulinemia (XLA), the markers are typically exploited in flow cytometry to diagnose the condition are C) CD19 and CD20

Step-by-step explanation:

The markers typically exploited in flow cytometry to diagnose X-linked agammaglobulinemia (XLA) are CD19 and CD20. CD19 is a cell surface protein found on B cells, while CD20 is a transmembrane protein expressed on both B cells and a subset of T cells. In XLA, the absence of CD19 and CD20 markers on B cells can help in identifying the condition.

Unlike in XLA, natural killer (NK) cells are not involved in the diagnosis of the condition. NK cells are a different subset of lymphocytes, and their markers are not specific to XLA. Similarly, markers like CD3+ (found on T cells) and CD16+ and CD54+ (not specific to B cells) are not utilized in the diagnosis of XLA.

In summary, the markers typically exploited in flow cytometry to diagnose X-linked agammaglobulinemia (XLA) are CD19 and CD20, as their absence on B cells can indicate the condition. Therefore the correct answer is C) CD19 and CD20

User Jdmonty
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