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"What cytokine, produced by macrophages, promotes the differentiation of Th1 cells from naïve CD4+ T cell pools?

A. Interleukin-12 (IL-12)
B. GM-CSF
C. Interleukin-1 (IL-1)
D. MCP
E. Transforming Growth Factor-beta (TGF-β)"

User Servy
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Final answer:

Option (A), The cytokine that stimulates the differentiation of Th1 cells from naive CD4+ T cell pools is Interleukin-12 (IL-12), vital for the TH1-mediated immune response.

Step-by-step explanation:

The cytokine produced by macrophages that promotes the differentiation of Th1 cells from naive CD4+ T cell pools is Interleukin-12 (IL-12). IL-12 plays a crucial role in the differentiation process by influencing naive T cells to develop into Th1 cells, which then secrete their own cytokines to orchestrate immune responses against intracellular pathogens such as Mycobacterium tuberculosis.

IL-12 is essential in the TH1-mediated response, which gears the immune system toward battling intracellular invaders and, as part of this response, helps macrophages enhance their pathogen digestion capabilities.

User Vitorio
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