Question

What is required for the activation of a naive B cell?

a) Interaction with dendritic cells.
b) Turnover of cytoplasmic molecules by proteasomes.
c) Engagement of its B cell receptor and secondary signals from CD4+ Th2 cells.
d) Isotype switching of immunoglobulins.
e) Engagement of its B cell receptor and direct interaction with antigen alone.

Answer 1

The activation of a naive B cell requires the engagement of its B cell receptor and secondary signals from CD4+ Th2 cells. This interaction between the B cell and the antigen leads to the development of plasma cells.

Step-by-step explanation:

The activation of a naive B cell requires the engagement of its B cell receptor and secondary signals from CD4+ Th2 cells. When a B cell encounters its matching antigen, it engulfs it and displays fragments of the antigen on its surface. This attracts a helper T cell, which binds to the B cell at the antigen site and releases cytokines that signal the B cell to develop into a plasma cell.