Final answer:
Option (a), The tissue-resident cell that responds to PAMPs and releases histamine and eicosanoids during an immune response is the basophil, not the macrophage.
Step-by-step explanation:
The tissue-resident cell that responds to pathogen-associated molecular patterns (PAMPs) and releases histamine and eicosanoids during an immune response is a basophil. Basophils are a type of white blood cell that are capable of producing and releasing histamine and other mediators, which are involved in the inflammatory response.
While macrophages are also involved in the immune response and are capable of phagocytizing pathogens, they are usually not the cells responsible for releasing histamine. Rather, macrophages produce chemicals that promote inflammation and can phagocytize pathogens to contribute to the defense against infection.