Question

What is the primary role of CD4+ Th1 cells in the immune response?

a) Recruit and activate macrophages to destroy intracellular pathogens.
b) Mediate allergic reactions by releasing histamine.
c) Directly kill virus-infected cells.
d) Regulate the differentiation of B cells into plasma cells.
e) Coordinate the function of cytotoxic T lymphocytes.

Answer 1

CD4+ Th1 cells' main function is to recruit and activate macrophages, aiding in the destruction of intracellular pathogens by releasing specific cytokines that enhance other immune cells' capabilities.

Step-by-step explanation:

The primary role of CD4+ Th1 cells in the immune response is to recruit and activate macrophages to destroy intracellular pathogens. Th1 cells secrete cytokines that are crucial for the stimulation and coordination of other cells involved in both innate and adaptive immunity. In particular, Th1 cells enhance the abilities of cytotoxic T cells (Tc cells) and support the functions of macrophages and neutrophils, which specialize in the destruction of intracellular bacteria like Mycobacterium tuberculosis. Additionally, Th1 cells work in conjunction with natural killer (NK) cells to bolster their ability to eliminate target cells, including tumor cells.