Question

Where are γδ T cells predominantly found in the body, and how does their recognition repertoire compare to αβ T cells?

a) Predominantly found in the respiratory organs, skin, and peritoneal cavity; their recognition repertoire is less extensive than that of αβ T cells.
b) Predominantly found in the spleen and peripheral lymph nodes; their recognition repertoire is more extensive than that of αβ T cells.
c) Predominantly found in the bone marrow; their recognition repertoire is equal to that of αβ T cells.
d) Predominantly found in the thymus; their recognition repertoire is highly specific, but not diverse.
e) Predominantly found in the central nervous system; their recognition repertoire is significantly more diverse than that of αβ T cells.

Answer 1

γδ T cells are predominantly found in the body in option a) Predominantly found in the respiratory organs, skin, and peritoneal cavity; their recognition repertoire is less extensive than that of αβ T cells.

Step-by-step explanation:

γδ T cells, unlike αβ T cells, are predominantly found in non-lymphoid tissues, including the respiratory organs, skin, and peritoneal cavity. This distribution allows them to quickly respond to local infections and other challenges. The recognition repertoire of γδ T cells is indeed less extensive compared to αβ T cells.

While αβ T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules, γδ T cells recognize a diverse array of non-peptide antigens, such as phosphoantigens, lipids, and small molecules, often without the need for MHC presentation.

Understanding the distinct features of γδ T cells is vital in comprehending the overall complexity and diversity of the immune system. Their unique localization in peripheral tissues and distinct recognition repertoire highlight their specialized role in immune responses. The presence of γδ T cells in various tissues contributes to the body's defense against a wide range of pathogens and abnormal cells.

In summary, option (a) accurately characterizes the predominant locations of γδ T cells and highlights their recognition repertoire, providing insights into their specialized role within the immune system.