Final answer:
Condoleezza Rice replaced Colin Powell as Secretary of State after Powell served under President George W. Bush and opposed the Iraq invasion without UN support.
Step-by-step explanation:
Condoleezza Rice replaced Colin Powell as Secretary of State. Colin Powell, who was a well-respected general during Operation Desert Storm, was appointed Secretary of State by President George W. Bush and served until his replacement by Condoleezza Rice.
Powell was known for his strong opposition to the invasion of Iraq in 2003 without clear objectives and support from the United Nations, setting a high bar for his successor in addressing foreign policy and diplomatic challenges.