Final answer:
The Meccans refused to return the Muslims and cited religious differences.
Step-by-step explanation:
The Meccans reacted to King Negus's query about returning Muslims by B) refusing to return the Muslims and citing religious differences. Even though the Aksumite Kingdom in Ethiopia provided shelter and protection to Muslims fleeing Meccan persecution, the Meccans did not agree to return the Muslims. The Meccans and Muslims engaged in fierce battles, and it was only after Muhammad's victory and the city's conversion to Islam that the Muslims were able to return to Mecca.