Question

A person with Systemic Lupus Erythematosus could be found to have any of the following genetic deficiencies except.

A) Complement deficiency
B) HLA gene mutations
C) Immunoglobulin deficiency
D) T-cell dysfunction

Answer 1

Immunoglobulin deficiency (C) is not typically found in Systemic Lupus Erythematosus (SLE), while complement deficiencies, HLA gene mutations, and T-cell dysfunction are more closely associated with the disease.

Step-by-step explanation:

A person with Systemic Lupus Erythematosus (SLE) could have a variety of genetic deficiencies, but an immunoglobulin deficiency such as agammaglobulinemia is not typically found in SLE. Therefore, the correct answer is C) Immunoglobulin deficiency. Agammaglobulinemia is a genetic disease that results in a lack of production of antibodies. In SLE, the body's immune system mistakenly attacks its tissues, causing widespread inflammation and tissue damage. Key aspects involve deficiencies or dysfunctions in components of the immune system, including complement deficiency, HLA gene mutations, and T-cell dysfunction.

However, SLE does not usually result in immunoglobulin deficiencies such as those seen in agammaglobulinemia, which causes severe infections early in life and can be deadly. While SLE involves autoimmunity, it is the autoantibodies against the individual's own DNA and/or proteins that contribute to the pathophysiology, rather than a lack of immunoglobulins.