Question

The translocation associated with CML that is termed the Philadelphia chromosome is a result of a fusion between chromosomes:

A) 9 and 22
B) 3 and 17
C) 7 and 11
D) 5 and 20

Answer 1

The translocation associated with CML, known as the Philadelphia chromosome, is a result of a fusion between chromosomes 9 and 22. This fusion leads to the production of an abnormal protein involved in the development of CML.

Step-by-step explanation:

The translocation associated with Chronic Myelogenous Leukemia (CML) that is termed the Philadelphia chromosome is a result of a fusion between chromosomes 9 and 22. This translocation occurs when a segment of chromosome 9 and a segment of chromosome 22 break apart and switch places, resulting in the formation of a new fused chromosome. This abnormal chromosome leads to the production of the BCR-ABL fusion protein, which is an oncogenic tyrosine kinase that plays a role in the development of CML.