Final answer:
AB2 rated drugs can be substituted with AB3 drugs only with a doctor's approval as they have to ensure an acceptable risk assessment and consider state laws and individual patient circumstances for bioequivalent drugs.
Step-by-step explanation:
When considering the substitution of drugs with different therapeutic equivalents, like substituting AB2 rated drugs for AB3 drugs, it is important to understand the meaning behind these ratings. The United States Food and Drug Administration (FDA) assigns an AB rating to products that are bioequivalent, meaning they are expected to be equivalent in their effectiveness when administered in the same dosage. However, each drug has a unique rating, for instance, AB2 or AB3, indicating a specific bioequivalence relationship compared to the reference drug.
So, the answer to whether AB2 rated drugs can be substituted with AB3 drugs is c) Only with a doctor's approval. The physician in charge would need to check if the specific bioequivalence confirms that the drugs can be used interchangeably without posing risks or reducing effectiveness, as substitution policies can differ by state and individual circumstances.
It is essential to determine whether a drug is deemed to be suitable for administration to humans on the basis of an acceptable risk assessment. The choice to substitute must take into account the safety and health of the patient, using professional medical judgment.