Final answer:
The bulk densities of excipient and ADI powders can determine whether a need exists for a pre-processing step like dry granulation before tablet manufacturing.
Step-by-step explanation:
The need for a pre-processing step such as dry granulation before the manufacture of tablets can be determined by examining the bulk densities of excipient and ADI powders. Bulk density is a measure of how closely packed the particles are in a given volume.
If the bulk densities of the powders are too low, indicating poor flowability, dry granulation may be necessary to improve the particle packing and ensure uniform tablet formation.