Final answer:
The vulnerabilities that led to replacing Intel and AMD processors are Spectre and Meltdown as identified by US-CERT.
Step-by-step explanation:
The two vulnerabilities that necessitated replacing a significant number of Intel and AMD computer processors are A. Spectre and Meltdown. The US-CERT recognized these vulnerabilities as serious threats that could allow attackers to bypass system protections and access sensitive data. Spectre exploits the speculative execution feature to cause information leaks, while Meltdown breaks the mechanism separating user applications from the operating system, allowing programs to access memory and data they're not supposed to.