Final answer:
The issues of an overly strong national government, lack of a bill of rights, and loss of state sovereignty were concerns of the Anti-Federalists, who opposed the new Constitution and favored strong state governments and a weak national government.
Step-by-step explanation:
Concern over an overly strong national government, lack of a bill of rights, and loss of state sovereignty were all issues raised by the Anti-Federalists. They feared the new Constitution offered too much power to the national government, and without a bill of rights, individual liberties were at risk. Their objections were rooted in a preference for strong state governments and a weak national government. Prominent Anti-Federalists included figures like Patrick Henry and George Mason, who believed in the preservation of local autonomy and were skeptical of the centralized powers that the proposed Constitution would entail.
Despite the resistance, the Constitution ultimately garnered enough support with the promise that a Bill of Rights would be added, addressing the Anti-Federalists' concerns. This led to the ratification of the Constitution and the subsequent adoption of the Bill of Rights as the first ten amendments to the Constitution. These amendments specifically protect civil liberties and set limits on government power in the United States.