1. The coefficient in 2H2O means that there are 2 moles of that compound for every 1 mole of CH4 and CO2. If you had 1 mole of CH4 (and enough O2), you would produce 2 moles of H2O. The coefficients describe the ratio of moles in an equation.
2. It's the same for O2. There are 2 moles of O2 for every 1 mole of CH4. When reacting O2 with CH4, you need 2 moles of O2 (which is important if you need to know how much O2 to react with CH4).