Final answer:
Asthma affects both the respiratory system, which deals with breathing and the airways, and the circulatory system by making the heart work harder due to limited oxygen intake.
Step-by-step explanation:
Asthma primarily affects the respiratory system, as it is characterized by difficulty in breathing due to inflammation and constriction of the airways. Besides the evident impact on the respiratory system, asthma can also affect the circulatory system. During an asthma attack, the body may struggle to get enough oxygen into the blood, which can force the heart to work harder, thus impacting circulation. Therefore, the correct answer to Natalie's condition is A) Respiratory and Circulatory systems.