The statement that is most effectively supported by the data in the graph is: D) CNO-treated females showed more activity relative to saline- treated females than CNO-treated males showed relative to saline-treated males.
CNO-treated females showed an increase in activity from day 1 to day 7, followed by a decrease from day 7 to day 14. CNO-treated males showed a decrease in activity from day 1 to day 7, followed by an increase from day 7 to day 14.
Saline-treated females showed a relatively constant level of activity throughout the monitoring period. Saline-treated males showed a slight decrease in activity from day 1 to day 7, followed by a slight increase from day 7 to day 14.
In conclusion, statement D is the most effective way to complete the assertion based on the data in the graph. It accurately captures the relative changes in activity for each group and highlights the significant difference between CNO-treated females and CNO-treated males.