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What are the three major buffer systems of the body and how do they work?

User Hexabunny
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Final answer:

The body maintains pH balance through three major buffer systems: the bicarbonate buffer, the phosphate buffer, and the protein buffer systems. These systems work at different speeds to regulate blood pH, ensuring that cellular processes operate effectively.

Step-by-step explanation:

The Three Major Buffer Systems

The human body maintains pH equilibrium through several highly efficient buffer systems, which operate at varying speeds. The three major buffer systems of the body include:

  1. Bicarbonate Buffer System: The primary buffer system in blood and interstitial fluid, composed of bicarbonate (HCO3-) and carbonic acid (H2CO3). It manages pH by the reversible reaction between CO2 and water, forming carbonic acid which dissociates into bicarbonate and hydrogen ions.
  2. Phosphate Buffer System: This system functions within the cells and the kidneys, using phosphate ions to stabilize pH levels.
  3. Protein Buffer System: Proteins such as hemoglobin act as buffers by accepting or donating hydrogen ions. Plasma proteins buffer within the blood plasma, while other cellular proteins buffer within cells.

The bicarbonate buffer system is swift, responding to pH changes in mere seconds. In contrast, the respiratory tract can also help adjust the pH by regulating CO2 exhalation—a process that takes minutes. The renal system, while slower, helps regulate pH by excreting hydrogen ions and conserving bicarbonate over hours to days.

These buffer systems are crucial in maintaining the pH of the blood plasma within a narrow, healthy range, ensuring that cellular processes continue to function effectively. The body's acid-base balance is a delicate equilibrium that these buffers help to maintain, with each system complementing the others in function and speed.

User Eddie Monge Jr
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