Final answer:
The nursing assistant's best response would be to approach the patient with empathy and understanding and respect their autonomy in making decisions about their own care.
Step-by-step explanation:
The nursing assistant's best response in this situation would be to approach the patient with empathy and understanding. The nursing assistant should acknowledge the patient's refusal of medication and respect their autonomy in making decisions about their own care. The nursing assistant should also try to open up a dialogue with the patient, asking if there is any specific reason for refusing the medications and if there is anything else they can do to assist the patient. By providing a supportive and caring environment, the nursing assistant can help build trust and rapport with the patient, which may eventually lead to a willingness to accept medications.