Final answer:
The missing number in the series is 81, which follows the pattern of 3 raised to increasing powers.
Step-by-step explanation:
The missing number in the series 9, ____, 6561, 43046721 is determined by recognizing the pattern in the series.
Each number in the series can be expressed as 3 raised to increasing exponential powers.
Therefore, 9 is 3^2, and 6561 is 3^8.
To find the missing number which should be 3^4,
we calculate 3 to the power of 4 which is 81.
Hence, the correct option is A. 81.