Final answer:
The nurse should teach the client to take both isoniazid and rifampin with food, expect to take the medication for 2 to 3 months, and consider a recommended dosing schedule.
Step-by-step explanation:
The nurse should teach the client to take both isoniazid and rifampin with food to minimize gastrointestinal upset and enhance absorption of the medications. Taking the medications together once a day may add convenience and improve adherence, but it may not be the recommended dosing schedule. The client should expect to take the medication for 2 to 3 months, not weeks, as tuberculosis treatment typically lasts for several months to ensure complete eradication of the bacteria.