Final answer:
When examining the shape of the ligand to the shape of the receptor protein, we compare the conformational changes and interactions that occur during binding.
Step-by-step explanation:
When examining the shape of the ligand to the shape of the protein, we are comparing the conformational changes and interactions that occur during binding. The ligand binds to the receptor's extracellular domain, causing conformational changes in both the extracellular and intracellular domains. These conformational changes can lead to activation of the receptor's intracellular domain or its associated proteins