Final answer:
Rheumatic fever is an autoimmune sequel to a streptococcal infection, characterized by immune-mediated damage to cardiac, neuronal, and synovial tissues.
Step-by-step explanation:
Rheumatic fever is an autoimmune sequel to a streptococcal infection. It is characterized by immune-mediated damage to cardiac, neuronal, and synovial tissues. The antibodies produced in response to the streptococcal infection cross-react with proteins in these tissues, leading to various symptoms such as joint pain, heart valve damage, and heart murmurs.