Final answer:
Methamphetamine use is associated with various clinical manifestations including increased heart rate and blood pressure, euphoria and increased energy, agitation and paranoia, and insomnia and reduced appetite.
Step-by-step explanation:
The clinical manifestations that accompany methamphetamine use include:
- Increased heart rate and blood pressure: Methamphetamine stimulates the release of norepinephrine, a neurotransmitter that increases heart rate and constricts blood vessels, leading to elevated blood pressure.
- Euphoria and increased energy: Methamphetamine can cause a sense of intense happiness, pleasure, and increased energy due to its effects on the dopamine system in the brain.
- Agitation and paranoia: Methamphetamine can induce feelings of restlessness, irritability, and extreme anxiety, along with paranoid thoughts and behaviors.
- Insomnia and reduced appetite: Methamphetamine can disrupt sleep patterns, leading to difficulty falling asleep or staying asleep. It also suppresses appetite, leading to reduced hunger and weight loss.